Holger Steuber: search on Z-Library

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1

How Reliable Are Current Docking Approaches for Structure-Based Drug Design? Lessons from Aldose Reductase

Matthias Zentgraf, Holger Steuber, Cornelia Koch, Concettina La Motta, Stefania Sartini, Christoph A. Sotriffer, Gerhard Klebe

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 406 KB

english, 2007

2

Amphiphilic Block Copolymer Vesicles for Active Wound Dressings: Synthesis of Model Systems and Studies of Encapsulation and Release

Haas, Simon, Chen, Yizhou, Fuchs, Christian, Handschuh, Stephan, Steuber, Marc, Schönherr, Holger

Journal:

Macromolecular Symposia

Year:

2013

Language:

english

File:

PDF, 423 KB

english, 2013

3

An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase

Streib, Manuel, Kräling, Katja, Richter, Kristin, Xie, Xiulan, Steuber, Holger, Meggers, Eric

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

4

Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C 2 -Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors

Kuhnert, Maren, Blum, Andreas, Steuber, Holger, Diederich, Wibke E.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.65 MB

english, 2015

5

Macrocyclic Statine-Based Inhibitors of BACE-1

Alessandra Barazza, Marion Götz, Sergio A. Cadamuro, Peter Goettig, Michael Willem, Holger Steuber, Tanja Kohler, Anja Jestel, Peter Reinemer, Christian Renner, Wolfram Bode, Luis Moroder

Journal:

Year:

2007

Language:

english

File:

PDF, 696 KB

english, 2007

6

Tracing Changes in Protonation: A Prerequisite to Factorize Thermodynamic Data of Inhibitor Binding to Aldose Reductase

Holger Steuber, Paul Czodrowski, Christoph A. Sotriffer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.47 MB

english, 2007

7

Xanthomonine I-III: eine neue Klasse von Lassopeptiden mit einem Makrolactamring aus sieben Aminosäureresten

Hegemann, Julian D., Zimmermann, Marcel, Zhu, Shaozhou, Steuber, Holger, Harms, Klaus, Xie, Xiulan, Marahiel, Mohamed A.

Journal:

Angewandte Chemie

Year:

2014

Language:

german

File:

PDF, 999 KB

german, 2014

8

Merging the Binding Sites of Aldose and Aldehyde Reductase for Detection of Inhibitor Selectivity-determining Features

Holger Steuber, Andreas Heine, Alberto Podjarny, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 5.76 MB

english, 2008

9

[Topics in Medicinal Chemistry] Therapy of Viral Infections Volume 15 || Strategies for the Development of Influenza Drugs: Basis for New Efficient Combination Therapies

Diederich, Wibke E., Steuber, Holger

Year:

2015

Language:

english

File:

PDF, 1.46 MB

english, 2015

10

A Cancer-Indicative microRNA Pattern in Normal Prostate Tissue

Hellwinkel, Olaf, Sellier, Christina, Sylvester, Yu-Mi, Brase, Jan, Isbarn, Hendrik, Erbersdobler, Andreas, Steuber, Thomas, Sültmann, Holger, Schlomm, Thorsten, Wagner, Christina

Journal:

International Journal of Molecular Sciences

Year:

2013

Language:

english

File:

PDF, 263 KB

english, 2013

11

Structural Hot Spots Determine Functional Diversity of the Candida glabrata Epithelial Adhesin Family

Diderrich, Rike, Kock, Michael, Maestre-Reyna, Manuel, Keller, Petra, Steuber, Holger, Rupp, Steffen, Essen, Lars-Oliver, Mösch, Hans-Ulrich

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 6.16 MB

english, 2015

12

Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution

Holger Steuber, Andreas Heine, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 3.55 MB

english, 2007

13

Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro−Fidarestat Complex

Petrova, Tatiana, Steuber, Holger, Hazemann, Isabelle, Cousido-Siah, Alexandra, Mitschler, Andre, Chung, Roland, Oka, Mitsuru, Klebe, Gerhard, El-Kabbani, Ossama, Joachimiak, Andrzej, Podjarny, Albert

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 254 KB

english, 2005

14

Fragment-Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition

Lisa Englert, Katrin Silber, Holger Steuber, Sascha Brass, Björn Over, Hans-Dieter Gerber, Andreas Heine, Wibke E. Diederich, Gerhard Klebe

Journal:

Year:

2010

Language:

english

File:

PDF, 707 KB

english, 2010

15

[Topics in Medicinal Chemistry] Therapy of Viral Infections Volume 15 || Targeting Cellular Cofactors in HIV Therapy

Diederich, Wibke E., Steuber, Holger

Year:

2015

Language:

english

File:

PDF, 534 KB

english, 2015

16

Tailored combinatorial microcompartments via self-organization of microobjects: Assembly, characterization and cell studies

Song, Qimeng, Steuber, Marc, Druzhinin, Sergey I., Schönherr, Holger

Journal:

Angewandte Chemie

Year:

2019

Language:

english

File:

PDF, 2.30 MB

english, 2019

17

Structure-Based Optimization of Aldose Reductase Inhibitors Originating from Virtual Screening

Michael Eisenmann, Holger Steuber, Matthias Zentgraf, Mirko Altenkämper, Regina Ortmann, Johann Perruchon, Gerhard Klebe, Martin Schlitzer

Journal:

Year:

2009

Language:

english

File:

PDF, 461 KB

english, 2009

18

[Topics in Medicinal Chemistry] Therapy of Viral Infections Volume 15 ||

Diederich, Wibke E., Steuber, Holger

Year:

2015

Language:

english

File:

PDF, 12.78 MB

english, 2015

19

Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals

Steuber, Holger, Hilgenfeld, Rolf

Journal:

Current Topics in Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.32 MB

english, 2010

20

An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 Å Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects

Dr. Holger Steuber

Journal:

Year:

2011

Language:

english

File:

PDF, 284 KB

english, 2011

21

Tracing Binding Modes in Hit-to-Lead Optimization: Chameleon-Like Poses of Aspartic Protease Inhibitors

Kuhnert, Maren, Köster, Helene, Bartholomäus, Ruben, Park, Ah Young, Shahim, Amir, Heine, Andreas, Steuber, Holger, Klebe, Gerhard, Diederich, Wibke E.

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

22

Tailored combinatorial microcompartments via self-organization of microobjects: Assembly, characterization and cell studies

Song, Qimeng, Steuber, Marc, Druzhinin, Sergey I., Schönherr, Holger

Journal:

Angewandte Chemie International Edition

Year:

2019

File:

PDF, 2.30 MB

2019

23

Tailored (Bio)Interfaces via Surface Initiated Polymerization: Control of Grafting Density and New Responsive Diblock Copolymer Brushes

Lilge, Inga, Steuber, Marc, Tranchida, Davide, Sperotto, Elena, Schönherr, Holger

Journal:

Macromolecular Symposia

Year:

2013

Language:

english

File:

PDF, 392 KB

english, 2013

24

Structural Basis for HTLV-1 Protease Inhibition by the HIV-1 Protease Inhibitor Indinavir

Kuhnert, Maren, Steuber, Holger, Diederich, Wibke E.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.22 MB

english, 2014

25

Photoinduced formation of stable Ag-nanoparticles from a ternary ligand-DNA-Ag + complex

Berdnikova, Daria V., Ihmels, Heiko, Schönherr, Holger, Steuber, Marc, Wesner, Daniel

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 828 KB

english, 2015

26

The E. coli Effector Protein NleF Is a Caspase Inhibitor

Blasche, Sonja, Mörtl, Mario, Steuber, Holger, Siszler, Gabriella, Nisa, Shahista, Schwarz, Frank, Lavrik, Inna, Gronewold, Thomas M. A., Maskos, Klaus, Donnenberg, Michael S., Ullmann, Dirk, Uetz, Pe

Journal:

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

27

[Topics in Medicinal Chemistry] Therapy of Viral Infections Volume 15 || HIV-1 Integrase Drug Discovery Comes of Age

Diederich, Wibke E., Steuber, Holger

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

28

Novel Dengue Virus NS2B/NS3 Protease Inhibitors

Wu, Hongmei, Bock, Stefanie, Snitko, Mariya, Berger, Thilo, Weidner, Thomas, Holloway, Steven, Kanitz, Manuel, Diederich, Wibke E., Steuber, Holger, Walter, Christof, Hofmann, Daniela, Weißbrich, Bene

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

29

[Topics in Medicinal Chemistry] Therapy of Viral Infections Volume 15 || Recent Advances in Targeting Dengue and West Nile Virus Proteases Using Small Molecule Inhibitors

Diederich, Wibke E., Steuber, Holger

Year:

2015

Language:

english

File:

PDF, 6.33 MB

english, 2015

30

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Wähler, Kathrin, Kräling, Katja, Steuber, Holger, Meggers, Eric

Journal:

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

31

Wie verlässlich sind aktuelle Docking-Ansätze für strukturbasiertes Wirkstoffdesign? – Fallstudie zur Aldose-Reduktase

Matthias Zentgraf, Holger Steuber, Cornelia Koch, Concettina La Motta, Stefania Sartini, Christoph A. Sotriffer, Gerhard Klebe

Journal:

Angewandte Chemie

Year:

2007

Language:

german

File:

PDF, 408 KB

german, 2007

32

[Topics in Medicinal Chemistry] Therapy of Viral Infections Volume 15 || Phosphonated Nucleoside Analogues as Antiviral Agents

Diederich, Wibke E., Steuber, Holger

Year:

2015

Language:

english

File:

PDF, 1.89 MB

english, 2015

33

Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models

Sugawara, Tatsuo, Baumgart, Simon J., Nevedomskaya, Ekaterina, Reichert, Kristin, Steuber, Holger, Lejeune, Pascale, Mumberg, Dominik, Haendler, Bernard

Journal:

International Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

34

Ein metallorganischer Inhibitor des humanen Reparaturenzyms 7,8-Dihydro-8-oxoguanosin-Triphosphatase

Streib, Manuel, Kräling, Katja, Richter, Kristin, Xie, Xiulan, Steuber, Holger, Meggers, Eric

Journal:

Angewandte Chemie

Year:

2014

Language:

german

File:

PDF, 1015 KB

german, 2014

35

Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons

Christof Gerlach, Michael Smolinski, Holger Steuber, Christoph A. Sotriffer, Andreas Heine, David G. Hangauer, Gerhard Klebe

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 518 KB

english, 2007

36

A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions

David Buttar, Nicola Colclough, Stefan Gerhardt, Philip A. MacFaul, Scott D. Phillips, Alleyn Plowright, Paul Whittamore, Kin Tam, Klaus Maskos, Stefan Steinbacher, Holger Steuber

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.46 MB

english, 2010

37

Thermodynamisches Inhibitionsprofil eines Cyclopentyl- und eines Cyclohexylderivats gegenüber Thrombin: gleich, jedoch aus unterschiedlichem Grund

Christof Gerlach, Michael Smolinski, Holger Steuber, Christoph A. Sotriffer, Andreas Heine, David G. Hangauer, Gerhard Klebe

Journal:

Angewandte Chemie

Year:

2007

Language:

german

File:

PDF, 518 KB

german, 2007

38

Tailored combinatorial microcompartments via self-organization of microobjects: Assembly, characterization and cell studies

Song, Qimeng, Steuber, Marc, Druzhinin, Sergey I., Schönherr, Holger

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 2.30 MB

english, 2019

39

Circulating miRNAs are correlated with tumor progression in prostate cancer

Jan C. Brase, Marc Johannes, Thorsten Schlomm, Maria Fälth, Alexander Haese, Thomas Steuber, Tim Beissbarth, Ruprecht Kuner, Holger Sültmann

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 378 KB

english, 2011

40

High-resolution Crystal Structure of Aldose Reductase Complexed with the Novel Sulfonyl-pyridazinone Inhibitor Exhibiting an Alternative Active Site Anchoring Group

Holger Steuber, Matthias Zentgraf, Alberto Podjarny, Andreas Heine, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 507 KB

english, 2006

41

Evolution of Flavone Synthase I from Parsley Flavanone 3β-Hydroxylase by Site-Directed Mutagenesis

Yvonne Helen Gebhardt, Simone Witte, Holger Steuber, Ulrich Matern and Stefan Martens

Journal:

PLANT PHYSIOLOGY

Year:

2007

Language:

english

File:

PDF, 2.47 MB

english, 2007

42

Interplay of Template Constraints and Microphase Separation in Polymeric Nanoobjects Replicated from Novel Modulated and Interconnected Nanoporous Anodic Alumina

Bayat, Haider, Lin, Chia-Hua, Cheng, Ming-Hsiang, Steuber, Marc, Chen, Jiun-Tai, Schönherr, Holger

Journal:

ACS Applied Nano Materials

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

43

Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions

Holger Steuber, Matthias Zentgraf, Christof Gerlach, Christoph A. Sotriffer, Andreas Heine, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.17 MB

english, 2006

44

Evidence for a Novel Binding Site Conformer of Aldose Reductase in Ligand-Bound State

Holger Steuber, Matthias Zentgraf, Concettina La Motta, Stefania Sartini, Andreas Heine, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.84 MB

english, 2007

45

Xanthomonins I-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring

Hegemann, Julian D., Zimmermann, Marcel, Zhu, Shaozhou, Steuber, Holger, Harms, Klaus, Xie, Xiulan, Marahiel, Mohamed A.

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 881 KB

english, 2014

46

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

Ferreira de Freitas, Renato, Eram, Mohammad S., Szewczyk, Magdalena M., Steuber, Holger, Smil, David, Wu, Hong, Li, Fengling, Senisterra, Guillermo, Dong, Aiping, Brown, Peter J., Hitchcock, Marion, M

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.43 MB

english, 2016

47

Chamäleon-artige Bindungsmodi in der Leitstrukturoptimierung: wechselnde Bindungsgeometrien bei Aspartylprotease-Inhibitoren

Kuhnert, Maren, Köster, Helene, Bartholomäus, Ruben, Park, Ah Young, Shahim, Amir, Heine, Andreas, Steuber, Holger, Klebe, Gerhard, Diederich, Wibke E.

Journal:

Angewandte Chemie

Year:

2015

Language:

german

File:

PDF, 1.21 MB

german, 2015

48

κ-Carrageenan Enhances the Biomineralization and Osteogenic Differentiation of Electrospun Polyhydroxybutyrate and Polyhydroxybutyrate Valerate Fibers

Goonoo, Nowsheen, Khanbabaee, Behnam, Steuber, Marc, Bhaw-Luximon, Archana, Jonas, Ulrich, Pietsch, Ullrich, Jhurry, Dhanjay, Schönherr, Holger

Journal:

Biomacromolecules

Year:

2017

Language:

english

File:

PDF, 9.18 MB

english, 2017

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